A paradigm shift occurs when laboratory-based research transfers into clinical practice for every-day patient care. Tissue engineering via the use of signaling molecules and morphogens in the form of rhBMP-2 is becoming increasingly popular for bone reconstruction. The movement from osteoconductive to osteoinductive regenerative materials and the use of space maintenance devices is an opportunity to solve many anatomic challenges with greater predictability and with less invasiveness. Tissue engineering is expanding the boundaries of reconstructive surgery and offers a novel opportunity to manage complex bone deformities in patients seeking implant rehabilitation. Faced with today’s clinical opportunities and patient demands, the need for predictable osteoinductive materials for vital bone is of greater importance to ensure successful outcomes.

This presentation will discuss and demonstrate the utilization of rhBMP-2 in reconstructive surgery. Cases demonstrating complex dentoalveolar bone reconstruction and craniofacial deformities will be presented with clinical re-entry and histologic evidence of de novo bone formation demonstrating how this paradigm shift has expanded capabilities and predictability to treat demanding cases.

Learning Objectives: Upon completion of this course, participants should be able to:
1. Understand how the process of fetal intramembranous bone development can be recapitulated in the adult skeleton to manage complex dentoalveolar reconstruction in patients seeking implant rehabilitation
2. Discuss how rhBMP-2 can offer a significant advantage to the surgical armamentarium of dentoalveolar bone and craniofacial reconstruction