The course will begin with an overview of indirect comparisons with a focus on scenarios in which an MAIC may be desirable. We will discuss examples of MAICs that have been submitted to major HTA agencies around the globe. Participants will subsequently review the most recent best practices and work through a complete example using simulated data. This process will include:

1. Assessment of the feasibility and appropriateness of MAIC
2. Identification of important prognostic and treatment effect modifying variables
3. Complete analysis of anchored and unanchored MAIC
4. Exploration of assumptions
5. Visualization and communication of MAIC results

Objectives:

Following this short-course, participants will:

• Understand the various indirect treatment comparison methodologies and when an MAIC should be considered;
• Be familiar with best practices for MAIC and their rationale;
• Be able to assess whether an MAIC is feasible;
• Understand methods for identification of prognostic and treatment effect modifying variables
• Have experience using code provided by the NICE TSD to run anchored and unanchored MAICs
• Be familiar with best practices for exploration/visualization of assumptions and results