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Chapter 1: Toward Global Biosafety Harmonization, Chapter 2: Emerging Challenges to Containment: Development of a Biodefense Infrastructure, Chapter 3: Brazilian Experience in Implementation of Biosafety Level 3 Laboratories (BSL-3), Chapter 4: Design Considerations for Large-Scale Production of Biologicals: GMP and Containment Synergies, Chapter 5: Animal Room Design Issues in High-Containment, Chapter 6: Mobile/Modular Containment Facilities, Chapter 7: Management of Multihazardous Wastes from High-Containment Laboratories, Chapter 8: Viral Genetic Diversity Network (VGDN) in Brazil, Chapter 9: Working Safely with the Transmissible Spongiform Encephalopathies